An insatiable Lionel Messi scored for the eighth game in a row in all competitions as La Liga champions Barcelona saw off a gutsy Girona side 2-0 to go five points clear at the top of the standings.
With Liverpool still to visit Chelsea, who trail them by nine points with two games in hand, Juergen Klopp's side may have to beat Brighton & Hove Albion on May 13 and rely on their superior goal difference to qualify for the Champions League, assuming they do not secure it by winning this year's trophy.
IMAGES from the English Premier League matches played on Tuesday
Images from the English Premier League matches played on Wednesday night.
Liverpool flirted with what would have been an embarrassing low in their poor start to the season as they were taken to penalties by fourth tier Carlisle United, but came through to reach the League Cup fourth round on Wednesday.
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A man who tried to rob Arsenal players Mesut Ozil and Sead Kolasinac at knifepoint in a failed North London carjacking last July was sentenced to 10 years in jail on Friday.
Spaniard Pedro scored twice as Chelsea tightened their grip on top spot by sweeping past Bournemouth 3-0 on Monday, a club record 12th successive Premier League win taking them seven points clear.
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Manchester United climbed back up to second in the table after second-half goals by Anthony Martial and Jesse Lingard earned a 2-0 victory at Everton -- their first win in five games in all competitions.
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Chelsea look capable of beginning a period of sustained domestic dominance. The average age of their squad is 26.9 -- with most of their key players in or approaching their prime years.
Chelsea overpowered West Ham United and Manchester City outclassed West Bromwich Albion as the Premier League title rivals signalled their intent at the start of a hectic holiday programme on Friday.
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Newcastle United's Papiss Cisse struck twice in a 2-1 victory against English Premier League leaders Chelsea.
Manchester City endured some anxious moments but escaped from fourth-tier Newport County with their FA Cup hopes intact as Phil Foden scored twice in an ultimately comfortable 4-1 fifth-round victory on Saturday.
Barcelona crashed out of the Champions League following a 3-0 defeat at Bayern Munich on Wednesday, failing to make it past the group stage of the competition for the first time since the 2000-01 season.
Liverpool scored a stunning 3-2 win over Queens Park Rangers with four of the five goals coming in the last seven minutes capping an astonishing finale to their Premier League match at Loftus Road on Sunday.
It is too early to say who has got the best of the most frenetic transfer market.
Frank Lampard and Edin Dzeko scored twice as holders Manchester City sailed into the English League Cup fourth round with a crushing 7-0 win over Sheffield Wednesday and Chelsea beat Bolton Wanderers 2-1 on Wednesday.
Frank Lampard could make an emotional appearance against former club Chelsea this weekend as his new employers Manchester City host Jose Mourinho's side in an early showdown between the Premier League's heavyweights. Catch all the action.
Manchester United's early season problems were compounded by a humiliating 4-0 loss to third-tier Milton Keynes Dons in the League Cup second round on Tuesday leaving new manager Louis van Gaal still looking for his first win.
Manchester United manager Jose Mourinho has promised to show plenty of restraint and respect if he inflicts a first Premier League defeat of the season on his former side Chelsea on Saturday.
Factbox on Jose Mourinho, who was named manager of Tottenham Hotspur on Wednesday
The Champions League quarter-final between Liverpool and Manchester City is one of the most anticipated games of the season pitting the Premier League's runaway leaders against the top scorers in Europe's elite competition.
Swedish striker Zlatan Ibrahimovic returned to Manchester United on a year-year contract "to finish what I started," the 35-year-old announced in a club statement on Thursday.
The FIFA 2022 World Cup will kick-off in Qatar on Sunday, November 20. Here is a list of the 26-man squads playing in the quadrennial global football extravaganza.
Manchester City thrashed Southampton 6-1 to remain top of the Premier League.
De Boer, who lasted only 77 days as Crystal Palace manager after losing his first four league games in charge with no goals scored, said in an interview on BT Sport that it was "a pity" Mourinho was Rashford's manager because he was not getting enough chances.
Here are five talking points from the weekend's Premier League action:
Leicester go five clear after win at Everton
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Arsenal manger Arsene Wenger remains on the hunt for striking options for his injury-hit squad despite being boosted by the return of forward Olivier Giroud for Monday's English Premier League clash at Aston Villa.
In the 69th minute, the Argentine slid in to meet a cross from Sterling and, although it appeared Mings got the final touch for an own goal -- ultimately, a decision for the dubious goals committee -- no-one was going to persuade Aguero that he was not responsible for putting City two up.
Bitter rivals Arsene Wenger and Jose Mourinho had wildly contrasting afternoons on Saturday as Arsenal went top of the Premier League and champions Chelsea lost again with their manager being sent off.
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Manchester City made it five wins out of five in the Premier League and Cristiano Ronaldo scored five goals for Real Madrid but Chelsea and Juventus continued to struggle at the weekend as the Champions League looms.
Manchester United manager David Moyes has warned his own player Ashley Young to stop diving but said on Monday he could not guarantee the winger would change his ways.
News of Van Gaal's impending departure from the club leaked out minutes after Saturday's 2-1 extra-time victory over Palace and, following relentless media speculation and a day of negotiations, it was confirmed by both sides on Monday evening.
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